Ccna2 Case Study 2012 Honda

Phase I:

Project Description

Network address: 192.168.10.0
Number of subnets: 5
Routing protocol: RIPv1

Tabella 1: Indirizzzamento


Phase II:

IP Addressing

Topologia

Phase III:

Basic Router and Workstation Configuration

Tabella 2: Riepilogo configurazione apparati

1. Configurazione router PA (Boaz):

hostname PA ! enable secret 5 $1$Bb13$JLdhMHQVN3E6eJAf7mBln0 ! ip subnet-zero ip host CT 192.168.10.33 192.168.10.65 192.168.10.1 ip host PA 192.168.10.62 192.168.10.97 ip host ME 192.168.10.129 192.168.10.94 ip host server1 192.168.10.2 ip host workstation3 192.168.10.98 ip host workstation4 192.168.10.99 ! interface Ethernet0 description Interfaccia FastEthernet0/0 - Lan sede di Palermo ip address 192.168.10.97 255.255.255.224 ip access-group 100 in ! interface Serial0 description Interfaccia Serial0/0 - DTE verso sede di Catania ip address 192.168.10.62 255.255.255.224 ! interface Serial1 no ip address shutdown ! interface Serial2 no ip address shutdown ! interface Serial3 no ip address shutdown ! interface BRI0 no ip address shutdown ! router rip network 192.168.10.0 ! ip classless access-list 100 permit ip 192.168.10.96 0.0.0.3 host 192.168.10.2 access-list 100 permit icmp 192.168.10.96 0.0.0.3 any echo-reply banner motd ^C HighNet Spa - Sede di Palermo ^C ! line con 0 password router#PA0 login line aux 0 line vty 0 4 password router#PA0 login ! end

2. Configurazione router CT (Center):

hostname CT ! enable secret 5 $1$ET6C$S1tz/J89qwr.LF9omjAS01 ! ip subnet-zero ! interface Ethernet0 description Interfaccia FastEthernet0/0 - Lan sede di Catania ip address 192.168.10.1 255.255.255.224 ! interface Serial0 description Interfaccia Serial0/0 - DCE verso sede di Palermo ip address 192.168.10.33 255.255.255.224 clockrate 4000000 ! interface Serial1 description Interfaccia Serial0/1 - DCE verso sede di Messina ip address 192.168.10.65 255.255.255.224 clockrate 4000000 ! interface Serial2 no ip address shutdown ! interface Serial3 no ip address shutdown ! interface BRI0 no ip address shutdown ! router rip network 192.168.10.0 ! ip host CT 192.168.10.33 192.168.10.65 192.168.10.1 ip host PA 192.168.10.62 192.168.10.97 ip host ME 192.168.10.129 192.168.10.94 ip host nfs 192.168.10.2 banner motd ^C HighNet Spa - Sede di Catania ^C ! line con 0 password router#CT0 login line aux 0 transport input all line vty 0 password router#CT0 login length 25 line vty 0 4 password router#CT0 login ! end

3. Configurazione router ME (Eva):

hostname ME ! enable secret 5 $1$qQfq$GJEjOjml7GVlLqE09IU5q1 ! memory-size iomem 25 ip subnet-zero ip host workstation6 192.168.10.131 ip host workstation5 192.168.10.130 ip host CT 192.168.10.33 192.168.10.65 192.168.10.1 ip host PA 192.168.10.62 192.168.10.97 ip host ME 192.168.10.129 192.168.10.94 ip host nfs 192.168.10.2 ! ! interface FastEthernet0 description Interfaccia FastEthernet0/0 - Lan sede di Messina ip address 192.168.10.129 255.255.255.224 ip access-group 101 in speed auto ! interface Serial0 description Interfaccia Serial0/0 - DTE verso sede di Catania ip address 192.168.10.94 255.255.255.224 ! router rip network 192.168.10.0 ! ip classless no ip http server ! access-list 101 permit ip 192.168.10.128 0.0.0.3 host 192.168.10.2 access-list 101 permit icmp 192.168.10.128 0.0.0.3 any echo-reply banner motd ^C HighNet Spa - Sede di Messina ^C ! line con 0 password router#ME0 login line aux 0 line vty 0 4 password router#ME0 login ! end

Phase IV:

Access Control Lists

Riportate nella sezione successiva

Phase V:

Documenting the Network

PA:

PA#show cdp neighbors Capability Codes: R - Router, T - Trans Bridge, B - Source Route Bridge S - Switch, H - Host, I - IGMP, r - Repeater Device ID Local Intrfce Holdtme Capability Platform Port ID CT Ser 0 140 R 2520 Ser 0 PA#show ip route Codes: C - connected, S - static, I - IGRP, R - RIP, M - mobile, B - BGP D - EIGRP, EX - EIGRP external, O - OSPF, IA - OSPF inter area N1 - OSPF NSSA external type 1, N2 - OSPF NSSA external type 2 E1 - OSPF external type 1, E2 - OSPF external type 2, E - EGP i - IS-IS, L1 - IS-IS level-1, L2 - IS-IS level-2, * - candidate default U - per-user static route, o - ODR Gateway of last resort is not set 192.168.10.0/27 is subnetted, 5 subnets C 192.168.10.96 is directly connected, Ethernet0 R 192.168.10.64 [120/1] via 192.168.10.33, 00:00:15, Serial0 C 192.168.10.32 is directly connected, Serial0 R 192.168.10.0 [120/1] via 192.168.10.33, 00:00:15, Serial0 R 192.168.10.128 [120/2] via 192.168.10.33, 00:00:15, Serial0 PA#show ip protocol Routing Protocol is "rip" Sending updates every 30 seconds, next due in 17 seconds Invalid after 180 seconds, hold down 180, flushed after 240 Outgoing update filter list for all interfaces is not set Incoming update filter list for all interfaces is not set Redistributing: rip Default version control: send version 1, receive any version Interface Send Recv Key-chain Ethernet0 1 1 2 Serial0 1 1 2 Routing for Networks: 192.168.10.0 Routing Information Sources: Gateway Distance Last Update 192.168.10.33 120 00:00:01 Distance: (default is 120) PA#show ip interface brief Interface IP-Address OK? Method Status Protocol BRI0 unassigned YES unset administratively down down BRI0:1 unassigned YES unset administratively down down BRI0:2 unassigned YES unset administratively down down Ethernet0 192.168.10.97 YES manual up up Serial0 192.168.10.62 YES manual up up Serial1 unassigned YES unset administratively down down Serial2 unassigned YES unset administratively down down Serial3 unassigned YES unset administratively down down PA#show version Cisco Internetwork Operating System Software IOS (tm) 2500 Software (C2500-IS-L), Version 11.2(11.1), MAINTENANCE INTERIM SOFTWARE Copyright (c) 1986-1998 by cisco Systems, Inc. Compiled Tue 13-Jan-98 21:09 by tlane Image text-base: 0x0302F1F4, data-base: 0x00001000 ROM: System Bootstrap, Version 11.0(10c), SOFTWARE BOOTFLASH: 3000 Bootstrap Software (IGS-BOOT-R), Version 11.0(10c), RELEASE SOFTWARE (fc1) PA uptime is 22 minutes System restarted by reload System image file is "flash:/c2500-is-l_112-111.bin", booted via flash cisco 2520 (68030) processor (revision N) with 6144K/2048K bytes of memory. Processor board ID 17602547, with hardware revision 00000003 Bridging software. X.25 software, Version 2.0, NET2, BFE and GOSIP compliant. Basic Rate ISDN software, Version 1.0. 1 Ethernet/IEEE 802.3 interface(s) 2 Serial network interface(s) 2 Low-speed serial(sync/async) network interface(s) 1 ISDN Basic Rate interface(s) 32K bytes of non-volatile configuration memory. 16384K bytes of processor board System flash (Read ONLY) Configuration register is 0x2102 PA#show hosts Default domain is not set Name/address lookup uses domain service Name servers are 255.255.255.255 Host Flags Age Type Address(es) CT (perm, OK) 0 IP 192.168.10.33 192.168.10.65 192.168.10.1 PA (perm, OK) 0 IP 192.168.10.62 192.168.10.97 ME (perm, OK) 0 IP 192.168.10.129 192.168.10.94 server1 (perm, OK) 0 IP 192.168.10.2 workstation3 (perm, OK) 0 IP 192.168.10.98 workstation4 (perm, OK) 0 IP 192.168.10.99 PA#show ip interface BRI0 is administratively down, line protocol is down Internet protocol processing disabled BRI0:1 is administratively down, line protocol is down Internet protocol processing disabled BRI0:2 is administratively down, line protocol is down Internet protocol processing disabled Ethernet0 is up, line protocol is up Internet address is 192.168.10.97/27 Broadcast address is 255.255.255.255 Address determined by setup command MTU is 1500 bytes Helper address is not set Directed broadcast forwarding is enabled Multicast reserved groups joined: 224.0.0.9 Outgoing access list is not set Inbound access list is 100 Proxy ARP is enabled Security level is default Split horizon is enabled ICMP redirects are always sent ICMP unreachables are always sent ICMP mask replies are never sent IP fast switching is enabled IP fast switching on the same interface is disabled IP multicast fast switching is enabled Router Discovery is disabled IP output packet accounting is disabled IP access violation accounting is disabled TCP/IP header compression is disabled Probe proxy name replies are disabled Gateway Discovery is disabled Policy routing is disabled Network address translation is disabled Serial0 is up, line protocol is up Internet address is 192.168.10.62/27 Broadcast address is 255.255.255.255 Address determined by setup command MTU is 1500 bytes Helper address is not set Directed broadcast forwarding is enabled Multicast reserved groups joined: 224.0.0.9 Outgoing access list is not set Inbound access list is not set Proxy ARP is enabled Security level is default Split horizon is enabled ICMP redirects are always sent ICMP unreachables are always sent ICMP mask replies are never sent IP fast switching is enabled IP fast switching on the same interface is enabled IP multicast fast switching is enabled Router Discovery is disabled IP output packet accounting is disabled IP access violation accounting is disabled TCP/IP header compression is disabled Probe proxy name replies are disabled Gateway Discovery is disabled Policy routing is disabled Network address translation is disabled Serial1 is administratively down, line protocol is down Internet protocol processing disabled Serial2 is administratively down, line protocol is down Internet protocol processing disabled Serial3 is administratively down, line protocol is down Internet protocol processing disabled PA#show ip access-lists Extended IP access list 100 permit ip 192.168.10.96 0.0.0.3 host 192.168.10.2 (6 matches) permit icmp 192.168.10.96 0.0.0.3 any echo-reply

CT:

CT#show cdp neighbors Capability Codes: R - Router, T - Trans Bridge, B - Source Route Bridge S - Switch, H - Host, I - IGMP, r - Repeater Device ID Local Intrfce Holdtme Capability Platform Port ID ME Ser 1 153 R 1720 Ser 0 PA Ser 0 140 R 2520 Ser 0 CT#show ip route Codes: C - connected, S - static, I - IGRP, R - RIP, M - mobile, B - BGP D - EIGRP, EX - EIGRP external, O - OSPF, IA - OSPF inter area E1 - OSPF external type 1, E2 - OSPF external type 2, E - EGP i - IS-IS, L1 - IS-IS level-1, L2 - IS-IS level-2, * - candidate default Gateway of last resort is not set 192.168.10.0 255.255.255.224 is subnetted, 5 subnets R 192.168.10.96 [120/1] via 192.168.10.62, 00:00:11, Serial0 C 192.168.10.64 is directly connected, Serial1 C 192.168.10.32 is directly connected, Serial0 C 192.168.10.0 is directly connected, Ethernet0 R 192.168.10.128 [120/1] via 192.168.10.94, 00:00:21, Serial1 CT#show ip protocol Routing Protocol is "rip" Sending updates every 30 seconds, next due in 2 seconds Invalid after 180 seconds, hold down 180, flushed after 240 Outgoing update filter list for all interfaces is not set Incoming update filter list for all interfaces is not set Redistributing: rip Routing for Networks: 192.168.10.0 Routing Information Sources: Gateway Distance Last Update 192.168.10.94 120 0:00:03 192.168.10.62 120 0:00:20 Distance: (default is 120) CT#show ip interface brief Interface IP-Address OK? Method Status Protocol BRI0 unassigned YES not set administratively down down Ethernet0 192.168.10.1 YES NVRAM up up Serial0 192.168.10.33 YES NVRAM up up Serial1 192.168.10.65 YES NVRAM up up Serial2 unassigned YES not set administratively down down Serial3 unassigned YES not set administratively down down CT#show version Cisco Internetwork Operating System Software IOS (tm) 3000 Software (IGS-IR-L), Version 11.0(13), RELEASE SOFTWARE (fc1) Copyright (c) 1986-1996 by cisco Systems, Inc. Compiled Mon 09-Dec-96 20:21 by athavale Image text-base: 0x03026008, data-base: 0x00001000 ROM: System Bootstrap, Version 5.2(8a), RELEASE SOFTWARE ROM: 3000 Bootstrap Software (IGS-RXBOOT), Version 10.2(8a), RELEASE SOFTWARE (fc1) CT uptime is 1 hour, 4 minutes System restarted by power-on System image file is "flash:igs-ir-l.110-13", booted via flash cisco 2520 (68030) processor (revision E) with 2048K/2048K bytes of memory. Processor board ID 04919552, with hardware revision 00000002 Bridging software. X.25 software, Version 2.0, NET2, BFE and GOSIP compliant. Basic Rate ISDN software, Version 1.0. 1 Ethernet/IEEE 802.3 interface. 2 Serial network interfaces. 2 Low-speed serial(sync/async) network interfaces. 1 ISDN Basic Rate interface. 32K bytes of non-volatile configuration memory. 8192K bytes of processor board System flash (Read ONLY) Configuration register is 0x2102 CT#show hosts Default domain is not set Name/address lookup uses domain service Name servers are 255.255.255.255 Host Flags Age Type Address(es) CT (perm, OK) 1 IP 192.168.10.33 192.168.10.65 192.168.10.1 PA (perm, OK) 1 IP 192.168.10.62 192.168.10.97 ME (perm, OK) 1 IP 192.168.10.129 192.168.10.94 server1 (perm, OK) 0 IP 192.168.10.2 workstation2 (perm, OK) 0 IP 192.168.10.3 CT#show ip interface BRI0 is administratively down, line protocol is down Internet protocol processing disabled Ethernet0 is up, line protocol is up Internet address is 192.168.10.1 255.255.255.224 Broadcast address is 255.255.255.255 Address determined by non-volatile memory MTU is 1500 bytes Helper address is not set Directed broadcast forwarding is enabled Outgoing access list is not set Inbound access list is not set Proxy ARP is enabled Security level is default Split horizon is enabled ICMP redirects are always sent ICMP unreachables are always sent ICMP mask replies are never sent IP fast switching is enabled IP fast switching on the same interface is disabled IP multicast fast switching is enabled Router Discovery is disabled IP output packet accounting is disabled IP access violation accounting is disabled TCP/IP header compression is disabled Probe proxy name replies are disabled Gateway Discovery is disabled Policy routing is disabled Serial0 is up, line protocol is up Internet address is 192.168.10.33 255.255.255.224 Broadcast address is 255.255.255.255 Address determined by non-volatile memory MTU is 1500 bytes Helper address is not set Directed broadcast forwarding is enabled Outgoing access list is not set Inbound access list is not set Proxy ARP is enabled Security level is default Split horizon is enabled ICMP redirects are always sent ICMP unreachables are always sent ICMP mask replies are never sent IP fast switching is enabled IP fast switching on the same interface is enabled IP multicast fast switching is enabled Router Discovery is disabled IP output packet accounting is disabled IP access violation accounting is disabled TCP/IP header compression is disabled Probe proxy name replies are disabled Gateway Discovery is disabled Policy routing is disabled Serial1 is up, line protocol is up Internet address is 192.168.10.65 255.255.255.224 Broadcast address is 255.255.255.255 Address determined by non-volatile memory MTU is 1500 bytes Helper address is not set Directed broadcast forwarding is enabled Outgoing access list is not set Inbound access list is not set Proxy ARP is enabled Security level is default Split horizon is enabled ICMP redirects are always sent ICMP unreachables are always sent ICMP mask replies are never sent IP fast switching is enabled IP fast switching on the same interface is enabled IP multicast fast switching is enabled Router Discovery is disabled IP output packet accounting is disabled IP access violation accounting is disabled TCP/IP header compression is disabled Probe proxy name replies are disabled Gateway Discovery is disabled Policy routing is disabled Serial2 is administratively down, line protocol is down Internet protocol processing disabled Serial3 is administratively down, line protocol is down Internet protocol processing disabled

ME:

ME#show cdp neighbors Capability Codes: R - Router, T - Trans Bridge, B - Source Route Bridge S - Switch, H - Host, I - IGMP, r - Repeater Device ID Local Intrfce Holdtme Capability Platform Port ID CT Ser 0 174 R 2520 Ser 1 ME#show ip route Codes: C - connected, S - static, I - IGRP, R - RIP, M - mobile, B - BGP D - EIGRP, EX - EIGRP external, O - OSPF, IA - OSPF inter area N1 - OSPF NSSA external type 1, N2 - OSPF NSSA external type 2 E1 - OSPF external type 1, E2 - OSPF external type 2, E - EGP i - IS-IS, L1 - IS-IS level-1, L2 - IS-IS level-2, ia - IS-IS inter area * - candidate default, U - per-user static route, o - ODR P - periodic downloaded static route Gateway of last resort is not set 192.168.10.0/27 is subnetted, 5 subnets R 192.168.10.96 [120/2] via 192.168.10.65, 00:00:24, Serial0 C 192.168.10.64 is directly connected, Serial0 R 192.168.10.32 [120/1] via 192.168.10.65, 00:00:24, Serial0 R 192.168.10.0 [120/1] via 192.168.10.65, 00:00:24, Serial0 C 192.168.10.128 is directly connected, FastEthernet0 ME#show ip protocol Routing Protocol is "rip" Sending updates every 30 seconds, next due in 22 seconds Invalid after 180 seconds, hold down 180, flushed after 240 Outgoing update filter list for all interfaces is not set Incoming update filter list for all interfaces is not set Redistributing: rip Default version control: send version 1, receive any version Interface Send Recv Triggered RIP Key-chain FastEthernet0 1 1 2 Serial0 1 1 2 Automatic network summarization is in effect Maximum path: 4 Routing for Networks: 192.168.10.0 Routing Information Sources: Gateway Distance Last Update 192.168.10.65 120 00:00:04 Distance: (default is 120) ME#show ip interface brief Interface IP-Address OK? Method Status Protocol FastEthernet0 192.168.10.129 YES NVRAM up up Serial0 192.168.10.94 YES NVRAM up up ME#show version Cisco Internetwork Operating System Software IOS (tm) C1700 Software (C1700-Y7-M), Version 12.2(4)T3, RELEASE SOFTWARE (fc3) TAC Support: http://www.cisco.com/tac Copyright (c) 1986-2002 by cisco Systems, Inc. Compiled Sun 10-Feb-02 02:57 by ccai Image text-base: 0x800080E0, data-base: 0x808258A4 ROM: System Bootstrap, Version 12.0(3)T, RELEASE SOFTWARE (fc1) ME uptime is 11 minutes System returned to ROM by reload System image file is "flash:c1700-y7-mz.122-4.T3.bin" cisco 1720 (MPC860) processor (revision 0x601) with 24576K/8192K bytes of memory. Processor board ID VMS062403PY (3200675184), with hardware revision 0000 M860 processor: part number 0, mask 32 Bridging software. X.25 software, Version 3.0.0. 1 FastEthernet/IEEE 802.3 interface(s) 1 Serial(sync/async) network interface(s) 32K bytes of non-volatile configuration memory. 8192K bytes of processor board System flash (Read/Write) Configuration register is 0x2102 ME#show ip hosts Default domain is not set Name/address lookup uses domain service Name servers are 255.255.255.255 Codes: u - unknown, e - expired, * - OK, ? - revalidate t - temporary, p - permanent Host Age Type Address(es) *p workstation6 0 IP 192.168.10.131 *p workstation5 0 IP 192.168.10.130 *p CT 0 IP 192.168.10.33 192.168.10.65 192.168.10.1 *p PA 0 IP 192.168.10.62 192.168.10.97 *p ME 0 IP 192.168.10.129 192.168.10.94 *p nfs 0 IP 192.168.10.2 ME#show ip interface FastEthernet0 is up, line protocol is up Internet address is 192.168.10.129/27 Broadcast address is 255.255.255.255 Address determined by non-volatile memory MTU is 1500 bytes Helper address is not set Directed broadcast forwarding is disabled Multicast reserved groups joined: 224.0.0.9 Outgoing access list is not set Inbound access list is 101 Proxy ARP is enabled Security level is default Split horizon is enabled ICMP redirects are always sent ICMP unreachables are always sent ICMP mask replies are never sent IP fast switching is enabled IP fast switching on the same interface is disabled IP Feature Fast switching turbo vector IP multicast fast switching is disabled IP multicast distributed fast switching is disabled IP route-cache flags are Fast Router Discovery is disabled IP output packet accounting is disabled IP access violation accounting is disabled TCP/IP header compression is disabled RTP/IP header compression is disabled Probe proxy name replies are disabled Policy routing is disabled Network address translation is disabled WCCP Redirect outbound is disabled WCCP Redirect inbound is disabled WCCP Redirect exclude is disabled BGP Policy Mapping is disabled Serial0 is up, line protocol is up Internet address is 192.168.10.94/27 Broadcast address is 255.255.255.255 Address determined by non-volatile memory MTU is 1500 bytes Helper address is not set Directed broadcast forwarding is disabled Multicast reserved groups joined: 224.0.0.9 Outgoing access list is not set Inbound access list is not set Proxy ARP is enabled Security level is default Split horizon is enabled ICMP redirects are always sent ICMP unreachables are always sent ICMP mask replies are never sent IP fast switching is enabled IP fast switching on the same interface is enabled IP Fast switching turbo vector IP multicast fast switching is disabled IP multicast distributed fast switching is disabled IP route-cache flags are Fast Router Discovery is disabled IP output packet accounting is disabled IP access violation accounting is disabled TCP/IP header compression is disabled RTP/IP header compression is disabled Probe proxy name replies are disabled Policy routing is disabled Network address translation is disabled WCCP Redirect outbound is disabled WCCP Redirect inbound is disabled WCCP Redirect exclude is disabled BGP Policy Mapping is disabled ME#show ip access-lists Extended IP access list 101 permit ip 192.168.10.128 0.0.0.3 host 192.168.10.2 permit icmp 192.168.10.128 0.0.0.3 any echo-reply

1. McLendon RE, Rich JN. Glioblastoma stem cells: A Neuropathologist's View. J Oncol. 2011;2011:397195. doi: 10.1155/2011/397195.[PMC free article][PubMed][Cross Ref]

2. States CBTRotU: CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2004–2006. 2010

3. Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, et al. European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups; National Cancer Institute of Canada Clinical Trials Group: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009;10:459–466. doi: 10.1016/S1470-2045(09)70025-7.[PubMed][Cross Ref]

4. Thumma SR, Fairbanks RK, Lamoreaux WT, Mackay AR, Demakas JJ, Cooke BS, Elaimy AL, Hanson PW, Lee CM. Effect of pretreatment clinical factors on overall survival in glioblastoma multiforme: A surveillance epidemiology and end results (SEER) population analysis. World J Surg Oncol. 2012;10:75. doi: 10.1186/1477-7819-10-75.[PMC free article][PubMed][Cross Ref]

5. Tseng YY, Liao JY, Chen WA, Kao YC, Liu SJ. Sustainable release of carmustine from biodegradable poly[(d,l)-lactide-co-glycolide] nanofibrous membranes in the cerebral cavity: In vitro and in vivo studies. Expert Opin Drug Deliv. 2013;10:879–888. doi: 10.1517/17425247.2013.758102.[PubMed][Cross Ref]

6. Gangemi RM, Griffero F, Marubbi D, Perera M, Capra MC, Malatesta P, Ravetti GL, Zona GL, Daga A, Corte G. SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity. Stem Cells. 2009;27:40–48. doi: 10.1634/stemcells.2008-0493.[PubMed][Cross Ref]

7. Clavreul A, Etcheverry A, Chassevent A, Quillien V, Avril T, Jourdan ML, Michalak S, François P, Carré JL, Mosser J, et al. Isolation of a new cell population in the glioblastoma microenvironment. J Neurooncol. 2012;106:493–504. doi: 10.1007/s11060-011-0701-7.[PubMed][Cross Ref]

8. Mao Y, Keller ET, Garfield DH, Shen K, Wang J. Stromal cells in tumor microenvironment and breast cancer. Cancer Metastasis Rev. 2013;32:303–315. doi: 10.1007/s10555-012-9415-3.[PMC free article][PubMed][Cross Ref]

9. Calon A, Espinet E, Palomo-Ponce S, Tauriello DV, Iglesias M, Céspedes MV, Sevillano M, Nadal C, Jung P, Zhang XH, et al. Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. Cancer cell. 2012;22:571–584. doi: 10.1016/j.ccr.2012.08.013.[PMC free article][PubMed][Cross Ref]

10. Östman A, Augsten M. Cancer-associated fibroblasts and tumor growth-bystanders turning into key players. Curr Opin Genet Dev. 2009;19:67–73. doi: 10.1016/j.gde.2009.01.003.[PubMed][Cross Ref]

11. López-Romero P, González MA, Callejas S, Dopazo A, Irizarry RA. Processing of agilent microRNA array data. BMC Res Notes. 2010;3:18. doi: 10.1186/1756-0500-3-18.[PMC free article][PubMed][Cross Ref]

12. Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43:e47. doi: 10.1093/nar/gkv007.[PMC free article][PubMed][Cross Ref]

13. Hulsegge I, Kommadath A, Smits MA. Globaltest and GOEAST: Two different approaches for gene ontology analysis. BMC Proc. 2009;3(Suppl 4):S10. doi: 10.1186/1753-6561-3-s4-s10.[PMC free article][PubMed][Cross Ref]

14. Kanehisa M, Goto S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28:27–30. doi: 10.1093/nar/28.1.27.[PMC free article][PubMed][Cross Ref]

15. Dennis G, Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 2003;4:P3. doi: 10.1186/gb-2003-4-5-p3.[PubMed][Cross Ref]

16. Zhao M, Sun J, Zhao Z. TSGene: A web resource for tumor suppressor genes. Nucleic Acids Res. 2013;41(Database issue):D970–D976. doi: 10.1093/nar/gks937.[PMC free article][PubMed][Cross Ref]

17. Chen JS, Hung WS, Chan HH, Tsai SJ, Sun HS. In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics. 2013;29:420–427. doi: 10.1093/bioinformatics/bts715.[PubMed][Cross Ref]

18. Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, Minguez P, Doerks T, Stark M, Muller J, Bork P, et al. The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 2011;39(Database issue):D561–D568. doi: 10.1093/nar/gkq973.[PMC free article][PubMed][Cross Ref]

19. Adamcsek B, Palla G, Farkas IJ, Derényi I, Vicsek T. CFinder: Locating cliques and overlapping modules in biological networks. Bioinformatics. 2006;22:1021–1023. doi: 10.1093/bioinformatics/btl039.[PubMed][Cross Ref]

20. Ding T, Ma Y, Li W, Liu X, Ying G, Fu L, Gu F. Role of aquaporin-4 in the regulation of migration and invasion of human glioma cells. Int J Oncol. 2011;38:1521–1531.[PubMed]

21. Baldwin RM, Barrett GM, Parolin DA, Gillies JK, Paget JA, Lavictoire SJ, Gray DA, Lorimer IA. Coordination of glioblastoma cell motility by PKCι Mol Cancer. 2010;9:233. doi: 10.1186/1476-4598-9-233.[PMC free article][PubMed][Cross Ref]

22. Schwartz GK, Shah MA. Targeting the cell cycle: A new approach to cancer therapy. J Clin Oncol. 2005;23:9408–9421. doi: 10.1200/JCO.2005.01.5594.[PubMed][Cross Ref]

23. Mo W, Chen J, Patel A, Zhang L, Chau V, Li Y, Cho W, Lim K, Xu J, Lazar AJ, et al. CXCR4/CXCL12 mediate autocrine cell-cycle progression in NF1-associated malignant peripheral nerve sheath tumors. Cell. 2013;152:1077–1090. doi: 10.1016/j.cell.2013.01.053.[PMC free article][PubMed][Cross Ref]

24. Huang TH, Huo L, Wang YN, Xia W, Wei Y, Chang SS, Chang WC, Fang YF, Chen CT, Lang JY, et al. EGFR potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Cancer Cell. 2013;23:796–810. doi: 10.1016/j.ccr.2013.04.027.[PMC free article][PubMed][Cross Ref]

25. Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO. Targets of the cyclin-dependent kinase Cdk1. Nature. 2003;425:859–864. doi: 10.1038/nature02062.[PubMed][Cross Ref]

26. Stegh AH, Brennan C, Mahoney JA, Forloney KL, Jenq HT, Luciano JP, Protopopov A, Chin L, Depinho RA. Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes Dev. 2010;24:2194–2204. doi: 10.1101/gad.1924710.[PMC free article][PubMed][Cross Ref]

27. Zhao R, Gish K, Murphy M, Yin Y, Notterman D, Hoffman WH, Tom E, Mack DH, Levine AJ. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev. 2000;14:981–993.[PMC free article][PubMed]

28. Levine A, Hu W, Feng Z. The P53 pathway: What questions remain to be explored? Cell Death Differ. 2006;13:1027–1036. doi: 10.1038/sj.cdd.4401910.[PubMed][Cross Ref]

29. Schwermer M, Lee S, Köster J, van Maerken T, Stephan H, Eggert A, Morik K, Schulte JH, Schramm A. Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors. Oncotarget. 2015;6:15425. doi: 10.18632/oncotarget.3908.[PMC free article][PubMed][Cross Ref]

30. Grabsch H, Takeno S, Parsons WJ, Pomjanski N, Boecking A, Gabbert HE, Mueller W. Overexpression of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in gastric cancer-association with tumour cell proliferation. J Pathol. 2003;200:16–22. doi: 10.1002/path.1324.[PubMed][Cross Ref]

31. Tang Z, Shu H, Qi W, Mahmood NA, Mumby MC, Yu H. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell. 2006;10:575–585. doi: 10.1016/j.devcel.2006.03.010.[PubMed][Cross Ref]

32. Ricke RM, Jeganathan KB, van Deursen JM. Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation. J Cell Biol. 2011;193:1049–1064. doi: 10.1083/jcb.201012035.[PMC free article][PubMed][Cross Ref]

33. Kawashima SA, Yamagishi Y, Honda T, Ishiguro K, Watanabe Y. Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin. Science. 2010;327:172–177. doi: 10.1126/science.1180189.[PubMed][Cross Ref]

34. Myrie KA, Percy MJ, Azim JN, Neeley CK, Petty EM. Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines. Cancer Lett. 2000;152:193–199. doi: 10.1016/S0304-3835(00)00340-2.[PubMed][Cross Ref]

35. Telentschak S, Soliwoda M, Nohroudi K, Addicks K, Klinz FJ. Cytokinesis failure and successful multipolar mitoses drive aneuploidy in glioblastoma cells. Oncology Rep. 2015;33:2001–2008.[PubMed]

36. Hadjihannas MV, Bernkopf DB, Brückner M, Behrens J. Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20. EMBO Rep. 2012;13:347–354. doi: 10.1038/embor.2012.12.[PMC free article][PubMed][Cross Ref]

37. Frescas D, Pagano M. Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: Tipping the scales of cancer. Nat Rev Cancer. 2008;8:438–449. doi: 10.1038/nrc2396.[PMC free article][PubMed][Cross Ref]

38. Wang Z, Wan L, Zhong J, Inuzuka H, Liu P, Sarkar FH, Wei W. Cdc20: A potential novel therapeutic target for cancer treatment. Curr Pharm Des. 2013;19:3210–3214. doi: 10.2174/1381612811319180005.[PMC free article][PubMed][Cross Ref]

39. Jiang J, Jedinak A, Sliva D. Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA. Biochem Biophys Res Commun. 2011;415:325–329. doi: 10.1016/j.bbrc.2011.10.055.[PubMed][Cross Ref]

40. Rajkumar T, Sabitha K, Vijayalakshmi N, Shirley S, Bose MV, Gopal G, Selvaluxmy G. Identification and validation of genes involved in cervical tumourigenesis. BMC Cancer. 2011;11:80. doi: 10.1186/1471-2407-11-80.[PMC free article][PubMed][Cross Ref]

41. Marucci G, Morandi L, Magrini E, Farnedi A, Franceschi E, Miglio R, Calò D, Pession A, Foschini MP, Eusebi V. Gene expression profiling in glioblastoma and immunohistochemical evaluation of IGFBP-2 and CDC20. Virchows Archiv. 2008;453:599–609. doi: 10.1007/s00428-008-0685-7.[PubMed][Cross Ref]

42. Bie L, Zhao G, Cheng P, Rondeau G, Porwollik S, Ju Y, Xia XQ, McClelland M. The accuracy of survival time prediction for patients with glioma is improved by measuring mitotic spindle checkpoint gene expression. PloS one. 2011;6:e25631. doi: 10.1371/journal.pone.0025631.[PMC free article][PubMed][Cross Ref]

43. Bae I, Rih JK, Kim HJ, Kang HJ, Haddad B, Kirilyuk A, Fan S, Avantaggiati ML, Rosen EM. BRCA1 regulates gene expression for orderly mitotic progression. Cell Cycle. 2005;4:1641–1666. doi: 10.4161/cc.4.11.2152.[PubMed][Cross Ref]

44. Bogdani M, Teugels E, De Grève J, Bourgain C, Neyns B, Pipeleers-Marichal M. Loss of nuclear BRCA1 localization in breast carcinoma is age dependent. Virchows Arch. 2002;440:274–279. doi: 10.1007/s004280100526.[PubMed][Cross Ref]

45. Lee C, Fotovati A, Triscott J, Chen J, Venugopal C, Singhal A, Dunham C, Kerr JM, Verreault M, Yip S, et al. Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice. Stem Cells. 2012;30:1064–1075. doi: 10.1002/stem.1081.[PubMed][Cross Ref]

46. Roshak AK, Capper EA, Imburgia C, Fornwald J, Scott G, Marshall LA. The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25c phosphatas. Cell Signal. 2000;12:405–411. doi: 10.1016/S0898-6568(00)00080-2.[PubMed][Cross Ref]

47. Casenghi M, Barr FA, Nigg EA. Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome. J Cell Sci. 2005;118:5101–5108. doi: 10.1242/jcs.02622.[PubMed][Cross Ref]

48. Feng Y, Yuan JH, Maloid SC, Fisher R, Copeland TD, Longo DL, Conrads TP, Veenstra TD, Ferris A, Hughes S, et al. Polo-like kinase 1-mediated phosphorylation of the GTP-binding protein Ran is important for bipolar spindle formation. Biochem Biophys Res Commun. 2006;349:144–152. doi: 10.1016/j.bbrc.2006.08.028.[PubMed][Cross Ref]

49. Hansen DV, Loktev AV, Ban KH, Jackson PK. Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC inhibitor Emi1. Mol Biol Cell. 2004;15:5623–5634. doi: 10.1091/mbc.E04-07-0598.[PMC free article][PubMed][Cross Ref]

50. Niiya F, Tatsumoto T, Lee KS, Miki T. Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA. Oncogene. 2006;25:827–837. doi: 10.1038/sj.onc.1209124.[PubMed][Cross Ref]

51. Foong CS, Sandanaraj E, Brooks HB, Campbell RM, Ang BT, Chong YK, Tang C. Glioma-propagating cells as an in vitro screening platform PLK1 as a case study. J Biomol Screen. 2012;17

0 thoughts on “Ccna2 Case Study 2012 Honda

Leave a Reply

Your email address will not be published. Required fields are marked *